Mississippi State University for Agriculture and Applied Science, commonly known as Mississippi State University (MSU), is a public land-grant research university adjacent to Starkville, Mississippi. It is classified among "R1: Doctoral Universities – Very High Research Activity" and has a total research and development budget of $239.4 million, the largest in Mississippi.

The university was chartered as Mississippi Agricultural & Mechanical College on February 28, 1878 and admitted its first students in 1880. Organized into 12 colleges and schools, the university offers over 180 baccalaureate, graduate, and professional degree programs, and is home to Mississippi's only accredited programs in architecture and veterinary medicine. Mississippi State participates in the National Sea Grant College Program and National Space Grant College and Fellowship Program. The university's main campus in Starkville is supplemented by auxiliary campuses in Meridian and Biloxi.

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