Northwestern State University of Louisiana (NSU) is a public university primarily situated in Natchitoches, Louisiana, with a nursing campus in Shreveport and general campuses in Leesville/Fort Polk and Alexandria. It is a part of the University of Louisiana System.

NSU was founded in 1884 as the Louisiana State Normal School. It was the first school in Louisiana to offer degree programs in nursing and business education. NSU, along with numerous other state colleges, gained university status in 1970 during the administration of President Arnold R. Kilpatrick, a Northwestern State alumnus who served from 1966 to 1978. Kilpatrick succeeded the 12-year president, John S. Kyser, a native of El Paso, Illinois.

NSU was one of the first six colleges to enter into NASA's Joint Venture Program. Students worked with NASA scientists to help analyze data and do research for the 1996 Space Shuttle Columbia shuttle mission. NSU also hosts the Louisiana Scholars' College, Louisiana's designated honors college in the liberal arts and sciences. The Louisiana School for Math, Science, and the Arts, a state-supported residential high school for sophomores, juniors, and seniors, is also located on the campus. It was a brainchild of former State Representative Jimmy D. Long of Natchitoches, who also attended NSU.

NSU offers more than 50 degree programs. Fall 2018 total enrollment was 11,081, the largest in the university's 133-year history. NSU also claims more than 70,000 alumni.

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