Southern Illinois University Edwardsville (SIUE) is a public university in Edwardsville, Illinois. SIUE was established in 1957 as an extension of Southern Illinois University Carbondale. It is the younger of the two major institutions of Southern Illinois University system, and, as of 2018, has the larger enrollment. The university offers graduate programs through its Graduate School.

The majority of SIUE's students are from Illinois, with out-of-state and international students accounting for 19% of enrollment. SIUE does offer in-state tuition for undergraduate students from all 50 states. The university offers numerous extracurricular activities to its students, including athletics, honor societies, student clubs and organizations, as well as fraternities and sororities. The university has more than 115,000 alumni.

Fielding athletic teams known as the SIU Edwardsville Cougars, the university participates in the National Collegiate Athletic Association (NCAA) at the Division I level as a member of Ohio Valley Conference (OVC).

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