The University of Louisville (UofL) is a public research university in Louisville, Kentucky. It is part of the Kentucky state university system. When founded in 1798, it was the first city-owned public university in the United States and one of the first universities chartered west of the Allegheny Mountains. The university is mandated by the Kentucky General Assembly to be a "Preeminent Metropolitan Research University". The university enrolls students from 118 of 120 Kentucky counties, all 50 U.S. states, and 116 countries around the world.

Louisville is classified among "R1: Doctoral Universities – Very high research activity". The University of Louisville School of Medicine is touted for the first fully self-contained artificial heart transplant surgery as well as the first successful hand transplantation in the United States. The University Hospital is also credited with the first civilian ambulance, the nation's first accident services, now known as an emergency department (ED), and one of the first blood banks in the US.

Louisville is also known for its Louisville Cardinals athletics programs. Since 2005, the Cardinals have made appearances in the NCAA Division I men's basketball Final Four in 2005, 2012, and 2013 (vacated), football Bowl Championship Series Orange Bowl in 2007 (champions) and Sugar Bowl in 2013 (champions), the College Baseball World Series 2007, 2013, 2014, 2017 and 2019, the women's basketball Final Four in 2009 (runner-up), 2013 (runner-up), and 2018, and the men's soccer national championship game in 2010. The Louisville Cardinals Women's Volleyball program has three-peated as champions of the Big East Tournament (2008, 2009, 2010), and were Atlantic Coast Conference Champions in 2015 and 2017. Women's track and field program has won Outdoor Big East titles in 2008, 2009 and 2010 and an Indoor Big East title in 2011.

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