Southeast Missouri State University (Southeast or SEMO) is a public university in Cape Girardeau, Missouri. In addition to the main campus, the university has four regional campuses offering full degree programs and a secondary campus housing the Holland College of Arts and Media. The university is accredited by the Higher Learning Commission.

Enrolling nearly 12,000 students, Southeast offers more than 175 undergraduate degree programs and 75 graduate programs. Originally founded in 1873 as a normal school, the university has a traditional strength in teacher education. In recent years, the university's reputation and focus has shifted towards the arts, with the construction of the River Campus creating the state's only campus entirely dedicated to the visual and performing arts. It is the only four year institution of higher education in the Southeast Missouri area.

Five academic units make up the university: the Holland College of Arts and Media; the Harrison College of Business and Computing; the College of Education, Health, and Human Studies; College of Humanities and Social Sciences; and the College of Science, Technology, Engineering, and Mathematics. The university's thirteen athletics teams compete in the Ohio Valley Conference of NCAA Division I and are known as the Southeast Missouri State Redhawks. The football team participates as part of the Football Championship Subdivision of Division I.

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